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During the 2007 (Kevin '07) election campaign, the Coalition run a "tough on drugs" platform amidst a media frenzy around Ben Cousins' drug struggles and the death of AFL player Chris Mainwaring.
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Mills had publicly pledged to crack down on wholesale drug trafficking into the UK via the airport and won the presidency on an anti-drugs platform.
A phase I trial in cancer patients supports the use of the anticalin drug platform for broad therapeutic and diagnostic applications [75].
Due to their promising anticancer activity in mouse colon carcinoma cells, the thiolated pectin DOX conjugates might be suitable for building drug platform for colorectal cancer-targeted delivery of DOX.
Meso-TR3 was generated by N-terminal insertion of soluble mesothelin into the TR3 drug platform.
Dirk Spitzer and William Hawkins own patent rights for the TR3 drug platform.
We have described the characterization of a downstream modification of the novel TRAIL-based drug platform TR3 which has many highly desirable anticancer properties.
Virotherapy with E1b55K-deleted adenoviruses (Ads), which preferentially replicate in cancer cells causing oncolysis and amplified efficacy, has been considered as an emerging drug platform [ 1].
Furthermore, genetic modification of the TR3 drug platform is feasible allowing delivery of preassembled bioactive TRAIL trimers to selected cell surface markers in a stoichiometrically-controlled fashion [ 12].
A rapidly determined patient-specific tumour mutation pattern combined with a flexible mutation-targeting drug platform could generate a mutation-targeting individualised therapy, which would benefit each single patient.
This finding was unexpected since we reported earlier that we had not observed detrimental effects on the killing activity of a variety of domain additions engineered onto the TR3 drug platform [ 12].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com