It can also provide a short cut to designing drugs which interact with that protein.
The eventual purpose is to design drugs which interact more with DNA.
The individual drug components in DCDB include 806 small compounds and 98 biotech drugs, which interact with 814 drug targets.
Ibuprofen is a well-known nonsteroidal anti-inflammatory drug, which can interact with lipid membranes.
As for the disease gene, side effects can be derived from the drug which is interacted with the disease gene.
Fluvastatin and rosuvastatin are primarily metabolized by CYP2C9, which interacts with drugs such as diclofenac and phenytoin [17], while pitavastatin is only marginally metabolized by CYP isoenzymes [26].
Indirect drug targets, along with direct drug targets, are proteins which interact with the direct drug targets based on the records of the IntAct database of protein protein interactions.
Last, because this study is based on cross-sectional data, our results could have been biased when persons with diagnosed/self-reported type 2 diabetes changed their lifestyle as a part of treatment or by any interaction with antidiabetic drugs, which may interact with iron concentrations (37).
Similarly PELP1 which interacts directly with STAT3 and is responsible for cell proliferation and survival in several tumours [ 53], is likewise an identified drug target in PDAC [ 60].
And since patients with heart failure typically take multiple drugs, which can interact and cause side effects like fatigue, getting rid of a drug that is not helping can be a huge benefit.
