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To assess the film loading capacity, piroxicam (PRX), a water insoluble drug, was selected.
Glycyrrhizin (GL), the bioactive drug was selected as a representative hydrophilic drug.
A challenging sustained release formulation with high content of a poorly flowing low density drug was selected.
As a model analyte, valproic acid (VPA, antiepileptic drug) was selected and its extraction from biological (human serum) and pharmaceutical (tablet and syrup) samples were performed without any considerable matrix effect.
The working range for the drug was selected to be 5 to 15 μg/mL.
In this work, atom types were made up of the 33 Tripos mol2 atom types [41] and other atom types that presented in the metabolic reactions, such as As, Pt, Co, Mn, Zn, Se, Ge, Sn, Gd and B. Celecoxib [42], a non-steroidal anti-inflammatory drug, was selected as an example of the construction of six layers topological atom fingerprints (Fig. 2).
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The drug vector [ lapatinib,AG825, AG1024, U0126, LY249002, Temsirolimus] indicates the drug selection where 1 means the drug is selected, while 0 means the drug is not used.
Finally the 25 lowest and the 25 highest ranked genes for each drug were selected to represent the initial set of genes to a build drug-specific gene network.
Each protein is then mapped in DrugBank, and those targeted by at least one drug are selected as a preliminary list of targets.
For example, if the response rates were independent identically distributed random variables then the probability that a drug is selected for the treatment of a samples is c/ d, the probability that a drug is selected for the treatment of at least one sample is 1- 1-c/d)s and the average number of drugs used for the treatment of at least one sample is d* = d[1- 1-c/d c/ d) s ].
Whichever drug is selected, introduction of vasopressors should be considered after optimal fluid loading; these agents may allow therapies to be applied earlier and more aggressively in order to improve physiological parameters and ultimately outcomes [ 48, 62].
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