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However, MDR1 over-expressing astrocytic cultures exposed to the same experimental paradigms showed drug uptake patterns similar to that observed in tumor cell cultures.
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Treatment failure may be explained by different patterns of drug uptake distribution.
Furthermore, the pattern of the subcellular photosensitiser distribution and the kinetics of drug uptake in HCT116 cells are in good agreement with previous findings of this laboratory in MCF-7 and V-79 cells that are known to be proficient in MMR (Hornung et al, 1997).
Figure 3 Measurement of cellular fluorescence and drug uptake.
Six studies assessed the influence of time on new drug uptake by encompassing many potential influencers for example, overall acceptance, growth in patient base, and the aggregate diffusion pattern in a geographic area.
Animals have a plethora of genetic, biochemical and physiological differences that alter disease progression, drug uptake, distribution and effect.
18F-FDG uptake patterns.
The in vitro drug release pattern of the drug showing an initial fast release within the first 6 h followed by an eventual gradual release over 72 h could well be exploited for therapy regimes spread out over long durations thereby reducing the frequency of drug uptake.
Both SLCO1B1 and ABCC1 transporters mediate drug uptake from the gastrointestinal tract and genetic variants alter drug uptake, resulting in differing drug responses.
This optical effect may be employed to improve the drug uptake properties of Fe3O4 nanoparticles.
The uptake patterns of amino acids from the media also altered depending on prevailing environmental conditions.
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