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It is also important to take into consideration the ADA assay performance in terms of drug tolerability before declaring a lack of ADA.
In recent years, direct-acting antivirals (DAAs), such as telaprevir (TPV), have been developed for chronic HCV infection in an effort to reduce therapy duration and increase drug tolerability, while also improving patient outcomes.
On the basis of these results, a dosing regimen was selected for the phase III Blockage of the Glycoprotein IIb/IIIa Receptor to Avoid Vascular Occlusion (BRAVO) trial based on pharmacodynamics and drug tolerability.
The second primary outcome was drug tolerability.
General patient safety and drug tolerability will be evaluated.
Drug tolerability was an important aspect of initial calls for uniocular trials [ 2].
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This study did not address different drug tolerabilities [ 5] which may or may not cause patients to discontinue therapy, nor did it address the concept of persistency.
These differences and the relative definition of the drugs' tolerability profiles are presumably related to the mechanism of action of each of the agents.
The drug's tolerability and clinical efficacy were also assessed.
A major problem concerning the addition of more drugs in a chemotherapy combination is designing a proper schedule assuring the balance between dose intensity (DI) of each drug and tolerability.
In light of relatively minor differences in terms of the glucose lowering efficacy between these drug classes, tolerability and absence of weight gain are key factors in the choice of the drug to be added to existing metformin plus SU therapy.
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