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TAC is a widely used antituberculosis drug that forms a second-line of therapy, often in conjunction with another drug, such as INH [42].
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A series of amide-coupled bisanthrapyrazole derivatives of 7-chloro-2-[2-[ 2-hydroxyethyl 7-chloro-2-[2-[ 2-hydroxyethyl 7-chloro-2-[2-[ 2-hydroxyethyl 7-chloro-2-[2-[ 2-hydroxyethyl 7-chloro-2-[2-[ 2-hydroxyethyl 7-chloro-2-[2-[ 2-hydroxyethyler drug that formed a strongly binding bisintercalation complex with DNA.
Certainly it must be concluded that all humans taking carboxylate drugs that form reactive acyl glucuronides will form covalent drug protein adducts, and it must also be concluded that this in itself is normally benign.
These cysteine residues are targets for various drugs that form Michael adducts with KEAP1 [9]–[12].
These drugs are two of the most effective and widely-used anti-TB drugs that form part of the standardized first-line regimen for drug-susceptible TB.
NSAIDs are effective analgesic and anti-inflammatory drugs that form the main pharmacological approach to treating various forms of pain, and particularly chronic musculoskeletal pain, but have a number of known adverse effects.
The significance of platelet abnormalities in the atherothrombotic process has been highlighted by the use of antiplatelet drugs that form part of the therapeutic regime in reducing cardiovascular risk [ 2].
The term 'antibiotic backbone' was coined to describe those drugs that form the foundation of antimicrobial therapy; these backbone antibiotics treat most bacterial infections effectively, and appropriate empirical use reduces both mortality and the emergence of resistance [ 1– 3].
Those developing DSSs might reject our blanket category, claiming significant differences between subclasses of these systems (e.g. how a specific tool works or is developed), in the same way that a chemist will recognise molecular differences between the individual drugs that form a single therapeutic class.
These include dietary control, gastroprotective drugs (drugs that form a protective bandage over inflamed tissue), prokinetics, and antacid medications (drugs that decrease stomach acid production).
This antibody is extremely specific for the EF5 drug adducts that form when the drug is incorporated by hypoxic cells (Lord et al, 1993).
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