Sentence examples for drug specificity from inspiring English sources

Interestingly, dATP treatment was reported to inhibit the 3′end processing of inflammatory genes without affecting the polyadenylation of control transcripts, indicating drug specificity for gene-specific differences in the 3′end processing step.

In addition, the drug delivery vehicle can be decorated with different functional groups which can be used to bind with the drug molecules or specific ligand molecules to enhance the drug specificity.

The results described in the present study provide insight into the molecular mechanism of action of the inhibitors as well as drug specificity that will assist in the development of more specific next generation CK2 inhibitors.

Therefore, it is imperative to study and understand the specific functions of individual HDACs in order to ascertain drug specificity and design targeted therapeutics with increased potency and minimal side effects.

This concept is validated by dynamically examining structural adaptations promoted by imatinib redesigns intended to control drug specificity.

These results suggest that targeting agents for a particular cell type can be incorporated with Pt-complexes using the rotaxane architecture to improve drug specificity.

The constitutively activated PDK1 AKT1 complex provides a cell-based platform to examine drug specificities in the PI3K pathway.

Observations on the redundancy and overlapping drug specificities of multidrug ABC transporters [27] and the examples of regulation of their expression independent of multiple drugs [28] have indicated that some of these ABC transporters might have alternative or additional physiological roles.

The MRP family currently has seven members, all with different drug specificities (Borst et al, 2000).

The otrC overexpressing cells showed a significantly enhanced MIC to ampicillin, OTC, doxorubicin, EB, ofloxacin and vancomycin, which indicated that OtrC functions as a drug exporter with a broad range of drug specificities.

Also, the susceptibilities of OtrC-overexpressing cells to several structurally unrelated drugs were compared with those of OtrC-non-expressing cells by minimal inhibitory concentration (MIC) assays, indicating that OtrC functions as a drug exporter with a broad range of drug specificities.