Sentence examples for drug platforms from inspiring English sources
Relatively little attention has been paid to higher nucleotides (corresponding to the natural di- and triphosphate DNA polymerase substrates) as drug platforms due to their expected poor deliverability.
The main idea behind most nanosized drug platforms relies on their potential to encapsulate the cargo and thereby shield it during transport to the site of action, and preventing its action prior to arrival.
Furthermore, novel drug platforms suitable for the on-demand production of GMP-quality individualised vaccines are emerging, including synthetic peptides (Yajima et al, 2005; Rammensee and Singh-Jasuja, 2013) and RNA (Kreiter et al, 2011b; Schlake et al, 2012).
A phase I trial in cancer patients supports the use of the anticalin drug platform for broad therapeutic and diagnostic applications [75].
Due to their promising anticancer activity in mouse colon carcinoma cells, the thiolated pectin DOX conjugates might be suitable for building drug platform for colorectal cancer-targeted delivery of DOX.
Meso-TR3 was generated by N-terminal insertion of soluble mesothelin into the TR3 drug platform.
Dirk Spitzer and William Hawkins own patent rights for the TR3 drug platform.
We have described the characterization of a downstream modification of the novel TRAIL-based drug platform TR3 which has many highly desirable anticancer properties.
Virotherapy with E1b55K-deleted adenoviruses (Ads), which preferentially replicate in cancer cells causing oncolysis and amplified efficacy, has been considered as an emerging drug platform [ 1].
Furthermore, genetic modification of the TR3 drug platform is feasible allowing delivery of preassembled bioactive TRAIL trimers to selected cell surface markers in a stoichiometrically-controlled fashion [ 12].
A rapidly determined patient-specific tumour mutation pattern combined with a flexible mutation-targeting drug platform could generate a mutation-targeting individualised therapy, which would benefit each single patient.
