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Due to their promising anticancer activity in mouse colon carcinoma cells, the thiolated pectin DOX conjugates might be suitable for building drug platform for colorectal cancer-targeted delivery of DOX.
A phase I trial in cancer patients supports the use of the anticalin drug platform for broad therapeutic and diagnostic applications [75].
The Shire-developed drug platform is generating other product candidates, including a treatment for a rare liver disorder called OTC deficiency.
Achillion's key drug platform is focused on inhibiting Factor D, and its pipeline contains drug candidates for rare diseases like PNH, as well as more common diseases like COPD and dry AMD.
Meso-TR3 was generated by N-terminal insertion of soluble mesothelin into the TR3 drug platform.
Dirk Spitzer and William Hawkins own patent rights for the TR3 drug platform.
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Relatively little attention has been paid to higher nucleotides (corresponding to the natural di- and triphosphate DNA polymerase substrates) as drug platforms due to their expected poor deliverability.
The main idea behind most nanosized drug platforms relies on their potential to encapsulate the cargo and thereby shield it during transport to the site of action, and preventing its action prior to arrival.
Furthermore, novel drug platforms suitable for the on-demand production of GMP-quality individualised vaccines are emerging, including synthetic peptides (Yajima et al, 2005; Rammensee and Singh-Jasuja, 2013) and RNA (Kreiter et al, 2011b; Schlake et al, 2012).
Continuing collaborations with Brigham and Women's Hospital and Massachusetts General Hospital are testing the folate-dual-drug platform against tumors in mice caused by TNBC cells implanted in them.
Mills had publicly pledged to crack down on wholesale drug trafficking into the UK via the airport and won the presidency on an anti-drugs platform.
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