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Drug loading, loading efficacy and release kinetics were determined.
The uniform design was used to optimize the technology of preparation, the appearance and size distribution were examined by scanning electron microscope, and the aspects such as in vitro release characteristics, stability, drug loading, loading efficiency, pharmacokinetics and tissue distribution in rabbit were studied.
The tubes were centrifuged (11,000 rpm, 10 minutes, 4°C) and aliquots were injected into the HPLC equipment to determine AR drug loading, loading efficiency, and entrapment efficiency.
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For determining the drug loading content (DLC) and drug loading efficiency (DLE), the DOX-loaded micelles were dissolved in DMF and stirred for 12 h at room temperature in the dark.
The drug loading and loading efficiency were 17.68 and 53.2%, respectively.
PLGA and polyvinyl alcohol concentrations had an important influence on drug loading: drug loading increased linearly with PLGA concentration and decreased linearly with PVA concentration.
The usefulness of the model in the design of loading experiments for desired drug loading efficiency and equilibrium loading was demonstrated by numerical analysis.
The nanogels can load cationic drugs such as doxorubicin with a high drug-loading capacity (48.3%) and drug loading efficiency (93.4%).
The dissolution profile and release model were evaluated with two different bupivacaine microspheres (bupi-MS) groups including low drug loading (6.41%) and high drug loading (28.92%).
The pSiO2 NSs with high specific surface area (835 m2·g− 1) and the pore volume (1.24 cm3·g− 1) are suitable for drug loading and the loading capacity reaches to 29% for amoxicillin (AMX) model drug.
We achieved controlled release rates of multiple antiretrovirals ranging from μg/d to mg/d by altering the orifice design, drug loading, and mass of pellets loaded in the device.
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