Sentence examples for drug loading increase from inspiring English sources
The use of PIBCA to form the core of the nanoparticles leads to a 2 4 fold drug loading increase, in comparison to the single PCL PEG nanoparticles.
With decrease in the polymer solution concentration, the percent yield and drug loading increase.
PLGA and polyvinyl alcohol concentrations had an important influence on drug loading: drug loading increased linearly with PLGA concentration and decreased linearly with PVA concentration.
The AQUA LNTs are pH responsive, and drug loading increased almost linearly by increasing the pH, reaching a maximum value (96%) at pH 9.0.
The numerical results showed that the rate of drug loading increased with increasing initial drug concentration in the solution or with the relative volume of the external solution and the microsphere.
The drug heterogeneity study showed that burst release (i.e. dose-dumping) increased as drug loading increased since the polymer could not form a gel layer to surround the tablet but the time taken for 99% drug release was not significantly different when compared to the homogeneous case.
Moreover, for the MNs with a 650-μm height, when increasing the viscosity of the coating solutions from 150 mPa·s to 1360 mPa·s, 2850 mPa·s, and 8200 mPa·s, the drug loading increased from 2.5 ng to 5 ng, 14 ng, and 22 ng per needle, respectively.
The particle size became big with the increase of drug loading, and the encapsulation efficiency also increased as drug loading increased from 5% to 7% but decreased significantly as drug loading further increased to 9%.
As a result, the drug loading increased with increase in the mole fraction of depsipeptide unit in the hydrophobic segments.
The thermal analysis by DSC also shows that the Tg of drug-PHEMA ASD decreases as the drug loading increases due to the plasticizing effect of dissolved drug on the polymer network (i.e., PHEMA has a Tg much higher than that of the model drugs).
The purpose of this work was to investigate and evaluate the powder compressibility of binary mixtures containing a well-compressible compound (microcrystalline cellulose) and a brittle active drug (paracetamol and mefenamic acid) and its progression after a drug load increase.
