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Nanoemulsions can be used to design delivery systems that have increased drug loading, enhanced drug solubility, increased bioavailability, controlled drug release, and enhanced protection against chemical or enzymatic degradation.
These include ease of preparation (due to spontaneous formation), thermodynamic stability, transparent and elegant appearance, increased drug loading, enhanced penetration through the biological membranes, increased bioavailability, and less inter- and intra-individual variability in drug pharmacokinetics.
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What's more, by utilizing the special structure of MSNRs, this nanocarrier can serve as a drug delivery platform with high drug loading capacity and enhanced cellular uptake efficiency.
The microporous scaffolds exhibited significantly enhanced drug loading capacity: 4 5 times increase in ampicillin and 9 10 times increase in cytochrome C compared to the non-microporous scaffolds.
The recognition cavities which caused by host-guest interactions had direct influence to enhanced drug loading and sustained release of CUR.
Their interior network acts as a drug reservoir providing enhanced drug loading by physical entrapment relative to non-crosslinked systems.
The encapsulation of drug in a nanoparticle offers numerous advantages such as high stability, enhanced drug loading, higher internalization, favorable biodistribution, and improved pharmacokinetics [14].
Fibrous ordered mesoporous carbon (FOMC) was developed as a new drug delivery system for loading an insoluble drug, designed to be orally administered, and then to enhance the drug loading capacity, improve the dissolution rate, enhance the oral bioavailability and reduce the gastric damage.
To enhance drug loading in chitosan, the mineral montmorillonite was incorporated into the matrix.
The liposome surface was modified with folate to enhance drug loading into cells, giving higher cytotoxic activity.
Prodrug-based self-assembled hydrogels are advantageous as they alter the solubility of the drug, enhance drug loading, and eliminate the use of harmful excipients.
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