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Formulation parameters such as PLGA molecular weight, concentration of ATV and PLGA in the coating solution and number of coatings were investigated to optimise the mesh in terms of drug loading efficacy, drug release kinetics and mechanical properties.
Physical properties of etoposide loaded micelles including particle size, zeta potential, and drug loading efficacy are presented in Table 2. Dialysis method was used to load the drug in the copolymeric micelles.
The post-insertion technique seems to be relatively simple, leads to an appropriate level of stable ligand incorporation, and is not compromising for drug loading efficacy and drug release profile [ 30].
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Drug loading, loading efficacy and release kinetics were determined.
However, the effect of NP drug loading on therapeutic efficacy and pharmacokinetics has not been thoroughly evaluated.
The mesoporous scaffolds were loaded with a small molecule hydrophobic drug to assess their drug loading and delivery efficacy.
It is concluded from Table 2 that by adding targeting ligand to particles both drug loading percent and efficacy have been decreased significantly (P < 0.05).
The samples were further investigated for their drug loading and release efficacy through RF activation of embedded MNS, which may stimulate triggered behavior and hence release the loaded therapeutics.
Moreover, previous report indicated that the temperature played an important role in controlling the swelling state of the poly-n-isopropylacrylamide (PNIPAM) as a thermoresponsive polymer which influenced the drug release and loading efficacy [ 39].
Evaluation of the drug-loading process indicates that drug deposition in the pores occurs during the loading process and the drug-loading efficacy is strongly related to the drug solubility.
It was found that the drug-loading efficacy and entrapment efficiency of PNIP/AAm nanogel particles for low molecular weight 5-Fu was higher than that for biomacromolecular BSA.
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