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Limited room for dose escalation due to limited drug loading b.
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Curve a, IBU hexane solution before drug loading; curve b, the SBF solution after the release of IBU-loaded SiO2 · Eu2O3 HSs for 4 h; curve c, the SBF solution after the release of IBU-loaded SiO2 · Eu2O3 HSs for 70.
PEG- b-PLGL micelle showed higher drug loading than PEG- b-PLGF micelle when the amount of FL in feed was high.
As a result, PEG- b-poly(lactide- co-depsipeptide) micelles showed higher drug loading compared with PEG- b-PLLA and PEG- b-PDLLA as controls.
The introduction of aliphatic or aromatic side-chain groups was effective to increase the drug loading, and DL values for PEG- b-PLGL and PEG- b-PLGF were increased with increasein the mole fraction of depsipeptide units.
The particle size and drug loading efficiency slightly decreased with increasing MPEG- b-PCL blend weight ratio.
A. Takahashi et al. reported impact of core-forming segment structure on drug loading in biodegradable polymeric micelles using PEG- b-poly(lactide- co-depsipeptide) block copolymers.
As it is seen from Table 2, the drug loading content of the 4-arm PEG-b-PAE micelles was 7.0 ± 0.2% and the encapsulation efficiency of the micelle was 85.2 ± 1.2%, which achieve high drug encapsulation efficiency.
Experiments using simulated gastric and intestinal fluids evidenced significant pH-dependent drug release behaviour of the nanoformulations loaded with Rhodamine B (RhB) as a model drug (loading capacity in excess of 83%), as monitored by UV Vis.
Surface characterisation of the CaCO3 nanocrystals by field emission scanning electron microscopy (FESEM) also displayed the rod shape of the particles before) and after the drug loading), confirming the structure shown by TEM and 1(b)).
Drug-loaded nanoparticles were prepared with initial drug loading of 5% (w/w of PLGA) paclitaxel.
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