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15 Within each therapeutic drug level, we separately estimated the prevalence of children presenting "recurrent/chronic" (three or more prescriptions a year) versus "non-recurrent" or "acute" drug use (less than three prescriptions a year), and the ratio between them to identify the treatments more commonly used for chronic than acute paediatric diseases.
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As we were unable to find experiments that reported drug exposure (e.g., drug serum levels), we calculated pooled effect sizes in OpenMeta[Analyst] and plotted against dose.
In light of the above, we made the following modifications to the manuscript: We added a statement in the Methods section as to why we used dose instead of drug exposure ("As we were unable to find experiments that reported drug exposure (e.g. drug serum levels), we calculated pooled effect sizes in OpenMeta[Analyst] and plotted against dose").
To further confirm that HIF1α-AGR2 affects MDR1-regulated drug intake levels, we treated cells with different concentrations of doxorubicin with or without CoCl2, in a doxorubicin cellular retention test, where the relative amount of doxorubicin absorbed in the cells could be reflected by the degree of red color in the cell pellets (Fig. 5d, e).
Strategies currently available, such as pill counting, serum drug level testing and electronic medication packaging, all have drawbacks.
The results revealed a strong correlation between the plasma drug level and the antipsychotic effect.
Vancomycin requires drug level monitoring and twice the dosage of Cubicin.
With pills, the drug level spikes after consumption, dropping as the time for the next dose approaches.
Routine drug level monitoring was not performed.
Among patients with supratherapeutic initial drug levels, five had a second drug level drug checked, and four (80%) remained supratherapeutic.
Standardized drug level monitoring schemes are in general highly recommended.
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