Sentence examples for drug layer from inspiring English sources
The bilayer-core consisted of two layers: (a) push layer and (b) drug layer, and was made with a modified upper tablet punch, which produced an indentation at the center of the drug layer surface.
Three separate layers, the drug layer, the barrier layer, and the enteric layer, were coated onto the inert core pellets.
No significant difference was observed between the dissolution profiles of orifice only on the side of the drug layer and orifices of the same diameter on both sides.
Polyethylene oxide 600,000 and 8,000,000 g/mole were used as thickening agent of drug layer and the expandable hydrogel of push layer, respectively.
The preparation of bilayer-core OPT was simplified by coating the indented core tablet, by which sophisticated technology of the drug layer identification and laser drilling could be eliminated.
In vitro drug release was studied; and the similarity between the conditions of orifice only on the side of the drug layer and orifices of the same diameter on both sides was evaluated.
This system composed of a middle push layer and attached drug layers of Nifedipine and Metoprolol.
The surprising difference in pellet morphology between the two solvent drug layering systems may be attributed to differences in solvent evaporation rates.
A solution to the problem was found in the incorporation of 10% v/v water into the ethanolic drug layering solution, resulting in the production of drug-loaded pellets with a smooth morphology which allowed the application of a coherent outer coating able to retard drug release.
In conclusion, it can be stated that the developed process for disintegrating pellets using non-aqueous granulating agents can be used as an alternative technique for various water sensitive drugs, circumventing the application of volatile organic solvents in conventional drug layering on inert cores.
The extended-release formulation of paliperidone consists of an osmotically active trilayer core, composed of two drug layers and a push layer (Conley et al. 2006), and can be administered once daily.
