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The process is automated for all possible combinations of the chemotherapy and immunotherapy drug dosages with preferential emphasis of having maximum possible variety of drug inputs at any given point of time.
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We further demonstrate the ability of our synthetic controllers to effectively modulate T-cell growth rate in response to drug input in vivo.
The design objective for modifying oral drug release is to alter the rate of drug input (dissolution/absorption) in the intestinal lumen to achieve a predetermined plasma profile.
Furthermore, a fuzzy logic based system is designed to classify drug responses according to sensitivity, using the drug input and mean arterial pressure (MAP) signals from the model.
However, if the AED is reformulated as an extended-release (XR) preparation, drug input may be prolonged relative to its immediate-release (IR) counterpart.
We also expand the analysis with two different extensions of the basic feedback model: one with a transduction step in the moderator and one which captures nonlinear phenomena (triggering mechanisms) caused by different drug input rates.
Various physical and chemical approaches have been successfully applied to produce well-characterized delivery systems that extend drug input into the GI tract within the specifications of the desired release profile.
The proposed control law is designed for the antiviral drug input such that the number of free viruses and consequently the number of infected cells decrease to the desired values.
However, termination of drug release from such a CRDDS at tdel and/or a declining drug input function towards the terminal phase of tdel from a first order kinetic CRDDS can have severe implications on plasma drug concentration and steady state fluctuations for a drug with very short half-life.
Deconvolution is a numerical method used to estimate the time course of drug input using a mathematical function.
For simplicity, the drug input rate is assumed to be constant with concentration approaching steady state after 10 time units.
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