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Similarly, the anticholinergic effects seem not to be related to the dosage of each individual drug, identifying the role of other factors in the development of cognitive deficits.
SRSF1-dependent AS of MNK2b following gemcitabine treatment conferred increased resistance of PDAC cells to chemotherapeutic drug, identifying a novel chemotherapy-mediated adaptation response through AS in PDAC cells [ 122].
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Ciprofloxacin is the only drug identified by the Food and Drug Administration as a treatment.
The last drug identified as a top performer from the (XP + P1) clustering results was the compound DB04860 (isatoribine).
"Within the limits of current technology by both laboratories," the statement read, "marijuana is the only drug identified in the body of Mr. Rudy Eugene".
The first known drug identified as an autophagy inducer is rapamycin, which was already in clinical use for other indications.
The date of the first drug identified during this time was considered the index date and the drug was designated as the index drug.
The UK team, working with colleagues in the US, Paris and Switzerland, screened more than 600 cancer cell lines with 130 drugs, identifying genetic signatures linked with drug sensitivity.
In addition, it is worth highlighting the following problems as best approached via combinatorial optimisation: drug discovery; optimising cocktails of known drugs; identifying targets for metabolic engineering.
For instance, most of the drugs identified as being "legal highs" are not in fact legal.
Fig. 11 Structures of the 22 active drugs identified from DrugBank screen.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com