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It can potentially validate inhibition of the molecular target of the drug; identify subgroups of patients who may not be candidates for the drug in question (triple negative tumours for EGFR inhibitors, to follow the example above); and provide knowledge to assist in a 'go versus no-go' decision regarding progression to phase II or III drug development.
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Ciprofloxacin is the only drug identified by the Food and Drug Administration as a treatment.
The last drug identified as a top performer from the (XP + P1) clustering results was the compound DB04860 (isatoribine).
"Within the limits of current technology by both laboratories," the statement read, "marijuana is the only drug identified in the body of Mr. Rudy Eugene".
The first known drug identified as an autophagy inducer is rapamycin, which was already in clinical use for other indications.
The date of the first drug identified during this time was considered the index date and the drug was designated as the index drug.
Such Big data-mining makes it possible to monitor for adverse drug events, profile specific drugs, identify off-label drug usage, uncover 'natural experiments' and evaluate difficult-to-test clinical hypotheses.
It has been intensively employed to understand drug mechanism, identify drug targets, and find new uses for existing drugs.
For instance, most of the drugs identified as being "legal highs" are not in fact legal.
Of the drugs identified through CanSAR analysis, 18 are reported in the Genomics of Drug Sensitivity in Cancer database.
Among the drugs identified by the testers were cocaine, ecstasy and sambutamol, an asthma drug which taken in high doses can increase an athlete's endurance.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com