The best dataset obtained so far for the native PD 0305970-containing crystal extends up to 3.1 Å. Crystals soaked using other drugs as well as the crystals from which PD 0305970 was back-soaked out, diffracted to a lower resolution and did not show a clear and interpretable drug envelope in the 2Fobs-Fcalc maps after refinement.
19 Concealment of allocation was considered adequate if the investigators responsible for the selection of patients did not know before allocation which treatment was next in line (central randomisation, sealed, opaque, sequentially numbered assignment envelopes, coded drug packs, etc).
†Yes if investigators responsible for patient selection were unable to suspect before allocation which treatment was next in line (central randomisation, sequentially numbered, sealed, opaque assignment envelopes, coded drug packs).
Nanoparticles may be more cytotoxic than the free drug as the polymeric envelope protects the drug and prevents the drug from being degraded by the harsh in vivo environment (Panyam and Labhasetwar 2003; Torchilin 2005).
The determination of a drug's gastrointestinal solubility envelope provides useful limits that can potentially be applied to in silico modelling and in vivo experiments.
The shipping envelope and drug packaging was similar to a reported port security seizure one of the authors had seen at a public presentation by a Pfizer security expert.
U.S. households use an average of nine rolls of film per year, dropping them off in the tall photo envelopes that litter drug stores and photo shops.
College-age employees took orders, addressed envelopes, wrapped the drugs in newspaper and stuffed them into greeting cards.
There were also signs of drug use, including a glassine envelope on the ground and a red plastic container stuffed with hypodermic needles.
The arrest, and three others, resulted from a sting in which an undercover officer took a clerical job on the exchange floor and was able to buy drugs, packaged in stock exchange envelopes, from four people from July to September of last year, the Manhattan district attorney's office said.
This chorus of countries calling for a saner approach toward narcotics jived with the museum's efforts to push the envelope on the drug debate.
