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Studies in recent years have revealed candidate transport pathways including the mechanotransducer channel for drug entry into sensory cells.
Drug entry into the body of a helminth is a key factor in the efficacy of anthelmintics.
Where drug entry across the BBB is by passive diffusion, in silico models are beginning to be used for predicting permeability.
Drug entry across cornea and conjunctiva following topical administration is a formidable challenge due to highly lipophilic epithelial membrane with tight junctions.
A combination of techniques is still required to cover the range of drug entry and efflux mechanisms across the BBB, and to take into account metabolism at the BBB.
Higher throughout methods (cell- and non-cell-based; in silico modelling) can help in prediction of permeation, but a combination of techniques is still required to cover the range of BBB drug entry and efflux mechanisms.
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The database contained 7097 drug entries including 1826 FDA-approved drugs.
The database contains nearly 4800 drug entries including >1,350 FDA-approved small molecule drugs, 123 FDA-approved biotech (protein/peptide) drugs, 71 nutraceuticals and >3,243 experimental drugs.
It has a total of 6,827 drug entries including 1,431 FDA-approved small molecule drugs and 5,212 research compounds linked to 4,477 non-redundant protein sequences.
4338 non-redundant protein sequences are linked to these drug entries http://www.drugbank.ca Some of them can be directly used for docking-based IVS studies.
Until now, the database contains more than 1,000,000 binding data, for about 7997 protein targets and 453,657 small molecules http://www.bindingdb.org/bind DrugBank In the latest version (5.0), the database contains 8261 drug entries including 2021 FDA-approved small-molecule drugs, 233 FDA-approved biotech (protein/peptide) drugs, 94 nutraceuticals, and over 6000 experimental drugs.
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