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Our findings could open up unique possibilities for structure-guided drug engineering with the aim of discovering combretastatin variants with improved chemical properties and pharmacological profiles.
Calling the study a "clean, impressive piece of work," tumor biologist Lance Munn of Massachusetts General Hospital and Harvard Medical School in Boston predicts there'll be much more of this kind of "intelligent drug engineering" over the next 10 years as researchers learn more about the structure and function of proteins.
Given this possibility, we hypothesized that it might be possible to improve the drug's stability and thereby its retention in the particles by appropriate drug engineering.
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If Italy chose to transfer even a part of this financial support to scientific research, then developments in drug technology, engineering, and genetic therapies might well begin to overshadow the country's skills with the ball.
Last, but not least, this approach can be applied to a wide class of similar problems, such as analysis of influenza neuramidase-mutants resistant to drugs, protein engineering or efficient drug design.
Another stimulus emanates from the world of medicine: designer drugs, genetic engineering, cyber-prosthetics and advanced techniques in cosmetic surgery.
This chapter reviews different types of anticancer drugs and engineering techniques for obtaining efficient delivery systems in cancer treatment.
Applications of these engineered biomolecules in protein purification, controlled drug delivery, tissue engineering, and biosurface engineering are discussed.
Tissue-on-a-chip platforms are an emerging technology in drug discovery, tissue engineering and regenerative medicine (Borooah et al., 2013; Inoue and Yamanaka, 2011).
Here, we describe how this young technology is revolutionizing drug delivery, tissue engineering, and cancer therapy.
So far CNTs was considered to be one novel and emerging technology in gene or drug delivery, tissue engineering, and regenerative medicine.
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