Exact(3)
Mutant GABAA receptors (α1β2-R207Cγ2S) with lower GABA sensitivity showed higher drug efficiencies (slope factors=1.1±0.1 (triazolam), 1.1±0.1 (clotiazepam), 1.2±0.1 (midazolam)).
Low-passage human cancer cell lines are increasingly acknowledged as advantageous preclinical models for testing drug efficiencies and analyzing the molecular basis of drug sensitivity and resistance [ 36, 37].
In contrast to cell lines of high passage [ 31, 32], low-passage cancer cell lines well reflect the biology of the original tumor, such as growth behavior, morphology, and mutational profile and are, therefore, in our experience, a versatile tool to evaluate drug efficiencies in a preclinical context.
Similar(57)
PCI may induce a loss of drug efficiency, catheter thrombosis and embolism.
The control input is defined to be dependent on the drug dose and drug efficiency.
When employing 3D models for anticancer drug testing, the drug efficiency is significantly lower than in the monolayer culture.
According to the drug efficiency, the same quantity of etoposide was applied to the apoptosis analysis with another incubation of 24 h.
Drug efficiency delivery and release to target site play an important role in the treatment of cancer.
These artificial hollow tubular tissues would be used for drug efficiency evaluation and operative training as in vitro simulators.
For the fitness accuracy, the lower energy is associated with the greater binding activity which can also give rise to better drug efficiency.
Therefore, the published models for volume of distribution, unbound volume of distribution and drug efficiency are also discussed.
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