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Exact(24)
Similar results were obtained using Vinblastine, another microtubule-depolymerizing drug (data not shown).
As expected, downregulation of p53 dramatically reduced the apoptotic response to the chemotherapeutic drug (data not shown).
All drugs did not affect cell viability at the concentrations used as their effects were fully reversed 4 hours following washout of the drug (data not shown).
However, the lysis of the antibiotic-treated infected culture was also clearly affected, occurring more rapidly in the presence of the drug (data not shown).
At low concentrations (<0.3 µM), very few genes were regulated at the 24 and 48 hour time points by either drug (data not shown).
In addition, HCVpp pre-incubated at neutral or acidic pH with Arb, even at very high concentrations (100 µM), displayed similar morphology (visualized by transmission electron microscopy) as those observed in the absence of the drug (data not shown).
Similar(36)
While our data points overwhelmingly to the inhibition of the CMASs by TAC or SRI-224, overexpression of the CMAS genes as described here was unable to significantly alter the MICs against the drugs (data not shown).
There was a significant correlation between CrCl at admission and CL for all drugs (data not shown).
In the sub-analysis of co-user vs. drug-only users, the model included gender, and use of anticoagulants, analgesics and dermal drugs (data not shown).
Amongst the 85 isolates, 51% were MDR cases, and 48% were found to be INH monoresistant cases with or without resistance to other TB drugs (data not shown).
A single trial compared TMP-SMX with norfloxacin (Lolekha 1988 THA), but reported only diarrhoea duration; it found no significant difference between the drugs (data not shown).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com