The new rank is provided in Table 9 and demonstrates that upon introducing the similarity to a known active drug criteria (Kalydeco), the highest ranking library is now DIVERSet™-EXP.
19 The results of our research support the theory that orphan drugs may have higher WTP thresholds, as several submissions with higher-than-threshold ICERs were accepted on the basis of meeting orphan drug criteria.
In other cases, drivers for acceptance included addressing an unmet therapeutic need, demonstrating a clear and certain clinical benefit over the current standard of care, and meeting end-of-life or orphan drug criteria (Table S1).
The control group consisted of patients for whom a PDDI also was identified by the same drug criteria but prescribers for these patients did not receive a fax alert.
110 Reviews of explicit and implicit criteria have identified these and other problems such as failure to address drug drug interactions and drug duplication, errors in recommendations, underrepresentation of certain drug categories, inclusion of infrequently prescribed drugs, criteria that are inapplicable for all situations, disagreement between criteria and lack of organisation of criteria.
Clinical trial investigators denied that "rebound" was a problem, having relied on a drug "rebound" criterion biased against demonstrating withdrawal effects and lacking statistical power.
Moreover, confirming the status of each patient may not be necessary when the fraction of patients who meet the antimicrobial drug exposure criterion is within a stable range.
Approximately 9% of patients met the antimicrobial drug exposure criterion, and 3.2% had one of the discharge diagnoses of interest (Table 3).
But just 661, or 21percentt, met the drug agency criteria -- severe chest pain and no other surgical options.
For a cancer drug, these criteria could include anything from tumor shrinkage to survival.
