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Thus, we must begin to understand the links between genomic profile and drug context in early drug development.
An innovative procedure combining CS drug memory reconsolidation blockade and enhanced extinction of the drug context using d-cycloserine (DCS) was shown to have greater effectiveness and may have great promise (Torregrossa et al., 2010).
As discussed above, while this view appeals to a negative affective state and aversive motivational processes, these may also profoundly influence the development of S-R drug seeking habits, although this has never been studied in an addictive drug context.
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The approach I wish to highlight here, however, is prevention of relapse by using treatments that diminish the impact of drug-associated stimuli on drug seeking – although this is not to underestimate the impact of drug contexts, reviewed elsewhere (Crombag et al., 2008; Badiani, 2013; Bossert et al., 2013).
One such system could be an improved pharmacovigilance system to detect ADE patterns associated with a newly prescribed drug; however, identifying the offending drug is not easy in a multi-morbidity/multi-drug context, and pharmacovigilance systems also have an inbuilt epistemological problem, as the reporting process is subject to Type I and Type II errors [ 6].
(Licensing refusal is a not uncommon outcome in the orphan drugs context. Joppi et al (2009) found the success rate for applications to be 63%, compared with over 70% for drugs for non-orphan indications).
As secrecy is important in the drug discovery context, use of the downloadable files from ChEBI is preferred in this context rather than web service queries.
The actors in this movie are my mother (Colette Carroll) and myself (Nicole Carroll) are making a connection with the use of chocolate to create a new mind set in a drug using context.
In the drug using context, (R_{0}) tells us, on average, the total number of people that each single drug user will initiate to drug use through the drug using career.
On the side of computer assistance, the automated generation of such sketches becomes very difficult when it comes to multi-molecular arrangements such as protein-ligand complexes in a drug design context.
We develop an inter-fragment interaction energy (IFIE) analysis based on the three- and four-body corrected fragment molecular orbital (FMO3 and FMO4) method to evaluate the interactions of functional group units in structure-based drug design context.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com