Exact(14)
On binding DNA-aptamer:drug complexes to AuNPs, a maximum of 35 neomycin molecules were bound per AuNP.
The thermodynamic treatment of data proved that dendrimer drug complexes were stable at all pH with values of ΔG always negative.
Therefore, designing effective macromolecular drug complexes requires considerations to include that the selected drugs are stable enough and possesses sufficient biocompatible property, with effective tumor accumulation by EPR effect of the targeted tumors.
The tendency of CNP to form agglomerates is unique and could be useful in drug delivery systems to immobilize CNP and drug complexes in the targeted body regions and then slowly release active substance.
For his final year thesis, he studied crystal structures of zinc drug complexes and serendipitously produced the first example of a new kind of crystal, giving him a taste of the excitement of scientific discovery.
Because the immunophilins were implicated in the mechanism of action of immunosuppressant drugs early on, and the various immunosuppressant drugs provided excellent selective and high-affinity ligands for FKBP12 and cyclophilin A, three-dimensional structures of the free proteins and their drug complexes were avidly pursued.
Similar(46)
In summary, despite decades of enthusiasm for nanomedicine including liposomal, micellar and polymeric drug complex, there are several problems that need to be addressed.
The targetable drug complex can be prepared by selecting an appropriate biotinyl drug derivative and a biotinyl homing device and mixing them with avidin.
The study was designed to formulate tasteless complexes of ondansetron with ion exchange resin and evaluate molecular properties of drug complex.
The predicted properties inferred the drug complex to be non-carcinogenic, and non-mutagen and may display moderate irritancy.
Several macromolecular systems have been developed with a cytotoxic drug complexed or covalently bound to the carrier.
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