Sentence examples for drug cmax from inspiring English sources

Furthermore, the proposed electrodes were utilized for the determination of ROX in human plasma, where electrode B covers drug Cmax which indicated its applicability to pharmacokinetic, bioavailability and bioequivalent studies.

The only exception to this general conclusion was observed in class III drugs (high solubility, low permeability) with low intrinsic clearance for which the parent drug Cmax ratio in steady state shows higher sensitivity followed by the metabolite Cmax ratio in single dose.

Given the PK properties of the drug (Cmax), we appraised the hormonal results as the AUC of the 30 90-min 30 90-min

Additionally, significant increases of meropenem both in terms of the maximum concentration of drug (Cmax) and area under the concentration-time curve (AUC) (Table 1) were measured.

In addition, prediction of Cmax and Cmin, were considered because achieving similar drug Cmax and Cmin may be important for some drugs in which these measures are related to drug efficacy and/or toxicity.

For most drugs, this range is wide enough, and the maximum plasma concentration of the drug (Cmax) and the area under the plasma concentration time curve (AUC) achieved when the recommended doses of a drug are prescribed lie sufficiently above the minimum therapeutic concentration and sufficiently below the toxic concentration [ 2, 3].

The maximum observed drug concentration (Cmax; unit: ng/mL) and the time of Cmax (tmax; unit: h) was determined from the PK profile.

An exploratory analysis investigated the potential relationship between drug exposure (Cmax, Cmin, and AUC) and change in gallbladder size.

Immediately after the end of the LD (30 minutes, diluted in 100 mL of 0.9% NaCl), a 4-ml blood sample was taken to assess drug concentrations (Cmax).

A significant limitation of the current work is that exposure data in humans and animals was not integrated into the concordance analysis because plasma drug concentrations (Cmax) were not cited in the literature reviewed.

Administration of primaquine in combination with chloroquine resulted in significantly lower primaquine CL/ F (P = 0.0005) and V/ F (P = 0.0004) values than with primaquine administered alone, leading to significantly higher drug exposure (Cmax, P = 0.0004; AUC0-last, P = 0.0004; and AUC0-∞, P = 0.0005).