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In this study, we improved the drug capacity of the LND-mPoP-NPs in addition to lowering non-specific toxicity associated with the drug deficient mPoP-NPs.
They are expected to bring a long term view to the process development strategy that ensures SHE issues are raised and resolved, bulk drug capacity requirements are achieved and the most appropriate innovative technologies exploited.
This second generation polyacetals allowed higher drug capacity than the tert-polymer, a biphasic DES release profile at acidic pH and due to its controlled amphiphilic character readily formed micelle-like structures in solution.
A novel biomaterial poly ethylene glycol -block-poly(γ-cholesterol-l-glycol -block-polyCHLglycol -block-polyd synthesized by introducing cholesterol side chains into this pegylated poly(amino acid) copolymers to enlarge the core space to increase the drug capacity.
Minimally, the use of a supported LB introduces a modification that holds a lot of advantages, including high loading drug capacity and drug co-delivery.
Since two of the native carboxyl residues asp4 and asp5 were deleted it is important to note that by this genetic modification in the structure of the major coat protein-8 we have reduced the potential drug capacity by more then 60%.
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Drug-loading capacity and drug encapsulation were 7.5 and 56.8%, respectively.
On the basis of absorbency at 326 nm, the drug-loading capacity and drug encapsulation of HCPT-loaded nanoparticles were 7.5 and 56.8%, respectively.
The nanogels can load cationic drugs such as doxorubicin with a high drug-loading capacity (48.3%) and drug loading efficiency (93.4%).
However, there still remain two problems waiting to be solved, i.e., low drug-loading capacity and quick drug release.
The drug loading capacity and encapsulation efficiency are calculated as follows: drug loading capacity = weight of etoposide in ECCNSs weight of ECCNSs × 100%%.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com