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Blend formulations of SEDS (solution enhanced dispersion by supercritical fluids) budesonide and albuterol exhibited a significant drug content uniformity (7 9% RSD) improvement over micronized drug blends (16 20% RSD).
The objective of this study was to assess the performance of SCF-engineered budesonide and albuterol sulfate powder blends in passive dry powder inhalers (DPI) relative to micronized drug blends.
The polymer-drug blend encased in this husk was engineered to give a long hour, zero-order release kinetics for both types of drugs.
The viscosity of sodium alginate was used in such a way that the synthesis of a cross-linker free hydrogel-drug blend can be a reality.
Figure 6 DLE of drug-loaded blend nanoparticles.
Figure 2 Average particle sizes of drug-loaded blend nanoparticles.
Drug-loaded blend nanoparticles were prepared via a nanoprecipitation method.
(a) Tm, (b) melting enthalpy, and (c) crystallinity of drug-loaded blend nanoparticles.
The drug-loaded blend nanoparticles with MPEG-b-PDLL/MPEG b-PCL blend weight ratios of 100/0, 75/25, 50/50, 25/75, and 0/100 ( w/w) were investigated.
With the second method, when the drug was blended into a hyaluronan-methylcellulose hydrogel the release rate was similarly reduced, with full release occurring after three days.
Melting temperature and melting enthalpy depression of MPEG- b-PCL indicate the miscibility between MPEG- b-PDLL and MPEG- b-PCL components in the drug-loaded blend nanoparticle matrix.
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