Sentence examples for drug biodistribution patterns from inspiring English sources

Ex vivo imaging and fluorescence quantification from excised organs was performed to establish drug biodistribution patterns.

To determine both the intratumoral uptake of the drug and its biodistribution pattern, CT-26 tumour-bearing mice (mean tumour volume=176.9±29.8 mm) were treated i.p. with [I]ICEU at the MTD (13 mg kg−1; 74 kBq).

The SML liposomes have similar pharmacokinetic and biodistribution patterns as conventional phospholipid cholesterol liposomes but a slower rate of contents delivery into the tissue.

Liposomal formulations of VANH have already been manipulated and characterized, which was a mean of increasing their therapeutic index, reducing their toxicity and altering drug biodistribution.

As increasing interest turns toward intra-articular drug delivery routes, parallel interest has emerged in evaluating drug biodistribution, safety, and efficacy in preclinical models.

Based on the two time points, two possible biodistribution patterns were applied to evaluate the consequence of different kinetic profiles.

This model, a rat interleukin-1beta overexpression model, offers the ability to evaluate anti-interleukin-1 therapeutics for drug biodistribution, activity, and safety as well as the therapeutic relief of disease symptoms.

1, 4, 8– 10 Nanoparticle-mediated drug delivery introduces additional complexities in drug biodistribution.

To determine if ELP stabilization has the potential to shift biodistribution patterns of VCN, the systemic biodistributions of VCN, A192, and A192-VCN were compared using microPET imaging.

Numerous recent nanoscale drug delivery systems utilize responsiveness to biological stimuli to control drug biodistribution in vivo.

Barriers to effective drug biodistribution in the CNS compartment make this disease more challenging for systemic therapy modalities.