Sentence examples for drug binds with from inspiring English sources

Recent experiments in this series have revealed how a hypertension drug binds with a target (angiotensin-II) that helps regulate blood pressure, and provided key structural details for a cell signaling pathway in the human body (rhodopsin-arrestin) that regulates sensory and hormonal responses.

The drug binds with great affinity to the bacterial enzyme dihydrofolate reductase (DHFR) [21].

The drug binds with higher affinity to HRP II as compared to the heme moiety [ 61].

The drug binds with N7 of purine bases forming monoadducts which are later transformed into inter and intrastrand cross links by reaction of second reactive site of the drug with the second nucleobase.

Target-mediated drug disposition (TMDD) is the phenomenon in which a drug binds with high affinity to its pharmacological target site (such as a receptor) to such an extent that this affects its pharmacokinetic characteristics. 1 The aim of this Tutorial is to provide an introductory guide to the mathematical aspects of TMDD models for pharmaceutical researchers.

Glycine substitution of this residue destroyed binding to this site, whereas notably, TtgR has a second "general" binding site to which phloretin and other drugs bind with lower affinity, which is not dependent upon charged residues (29).

Part of phospholipids, which carry lipids in blood and help shuttle nutrients into and out of cells M: 700 mg, W: 700 mg 31 70 4,0000 mg 71+: 3,000 mg Wide variety of foods, including milk and dairy products, meat, fish, poultry, eggs, liver, green peas, broccoli, potatoes, almonds Certain drugs bind with phosphorus, making it unavailable and causing bone loss, weakness, and pain.

86 The drug binds tightly to DHFR, with an inhibitory constant (K i) of 0.35 pmol/L, 15-fold lower than for MTX.

This drug binds to the androgen receptor with high affinity and effects a more complete blockade of receptor signaling than earlier drugs, providing significant survival benefit in advanced castration-resistant prostate cancer (Scher et al., 2012).

In novel drug design, compounds are usually engineered to bind to a specific target, with the assumption that one drug binds to one target to treat one condition.

To design a pharmacologically active drug for site-specific activity is a challenging task that begins with rationally identifying the targets to which that drug binds.