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The value Di,j is therefore the total (scaled) adjacency of drug i with all predictors of type j.
This constitutes the activity profile of drug i.
For drug (i), the average of (D_{i, cdot }).
For drug (i), the average of (M_{i, cdot }).
If drug (i) has observed affinities with target (j)'s neighbours, average the values.
If target (j) has observed affinities with drug (i)'s neighbours, average the values.
The "gain score" for drug-treated individual i is defined as y drug, i gain = y drug, i post − y i pre .
The clinical performance of drug i on criterion k is denoted with θ ik.
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