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DEX1, DEX2, DEX3: Non-drug treated cells (Drug 0) or drug-treated cells (Drug 1, 2, 3) were treated with three different concentrations of DEX.
Suppose that Drug 1 is a sufficient means to relieving the patient's pain.
Fluorine-containing thiocyanate derivatives 2 and 3 were threefold more potent than our lead drug 1 against intracellular T. cruzi.
A doctor is sure to give Drug 1. Giving Drug 2, in addition, would at first neutralize the effect of Drug 1, but then recombine with it to produce a third drug, which will relieve the patient's pain.
Briefly, about 100 mg of polymer and drug (1%, w/w) were dissolved in 6 ml of acetonitrile.
Prodrugs with an ionized amino group at the solubilizing moiety exhibited a remarkable increase of water-solubility (>104 fold) compared to the parent drug 1.
Similar(26)
Mitelfosine, an alternative antileishmanial drug [ 1, 30, 31], has the advantage of oral administration.
Therefore, MGMT status is a strong predictor of response to treatment with temozolomide and it is determined in most ongoing clinical trials using this drug [ 1, 7, 8].
Upon UV irradiation, 2-nitrobenzyl moieties were selectively cleaved, leading to the release of a model drug, 1-pyrenebutyric acid.
Cardiac abnormalities and depression represent a contraindication for the use of this drug [1, 11, 31].
XDR strains of M. tuberculosis additionally are resistant to fluoroquinolones and at least one second-line drug [1].
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