No severe side effects were seen and the drop of serum calcium after the subcutaneous injection could be treated by oral calcium supplementation.
Even though a transient drop of serum calcium level after administration of bisphosphonates may happen, whether such a drop of serum calcium can trigger AF is again, elusive.
Khouri et al. have reported a fast drop of serum concentrations in patients with active ALL or CLL.
Over the ensuing two days, a significant drop of serum creatinine was observed with lowest values observed at ICU discharge (Table 3).
Qualitative C-reactive protein (CRP) was measured using the latex immunoassay on one drop of serum (Human Gesellschaft fur Biochemica und Diagnostica mbH, Germany).
One drop of CRP latex reagent was added to the drop of serum and the broad end of the pipette was used to spread the latex reagent over the entire area of the test circle.
Rebleeding was defined as observation of red blood in the stomach, a drop of serum hemoglobin more than 2 gr/dl during 24 hours, continuous melena for more than 7 days, or instability of vital signs (defined as a pulse rate more than 110 per minute, positive tilt sign, or a drop of systolic blood pressure below 90 mmHg in supine position).
However, a significant drop of serum level of each miR (including miR-19a) was noted after the therapy at time point III compared to the time point I at diagnosis (p-values < 0.05, i.e., miR-155: 1.32e-09, miR-19a: 0.00869, miR1-81b: 8.80e-06, and miR-24: 0.02343, respectively).
