Visual dysfunction and psychological burden (awareness of diagnosis, knowledge of potential blinding states, inconvenience of eye drops, side effects of treatments, and aggravated economic burden) of glaucoma lead to reduced QoL.
In the four who dropped out, the side effects (edema in two, diarrhea in one, and heart palpitations in one) all resolved shortly after stopping celecoxib.
Of the four who dropped out, the side effects (edema in two, diarrhea in one, and heart palpitations in one) resolved shortly after stopping celecoxib.
The pharmacological reformulation of shorter acting mydriasis drops to minimise side effects may reduce disruption to patients and potentially benefit uptake rates, although we acknowledge that this would not address the pain participants had reported.
Existing literature has highlighted supplementation with iron syrup/drops or tablet being prone to poor adherence because of several factors that include difficulty swallowing tablets [ 7], drops having gastrointestinal side effects like abdominal discomfort, unpleasant and strong metallic taste, staining of a child's teeth if not wiped off immediately and complicated dosing instructions [ 8, 9].
If we doctors fully understand the paradigm of EBM, and clearly explain that the eye drop sometimes has side effects and is not very effective, we'll succeed in persuading patients.
Reasons for drop out included: side effects (n = 4); new health issues (n = 2); no explanation provided (n = 4); left area (n = 1); switched to glatiramer acetate per patient preference (n = 1); sample hybridization not adequate at baseline or 6 month injection (n = 2).
Patients receiving adalimumab were also more likely to drop out because of side effects (NNH 47) and to suffer injection site reactions (NNH 22).
Patients receiving infliximab were more likely to drop out because of side effects (NNH 24) and to suffer severe side effects (NNH 31), infections (NNH 10) and infusion reactions (NNH 9).
Patients receiving etanercept were less likely to drop out because of side effects (NNH for control versus etanercept 26) but more likely to experience injection site reactions (NNH 5).
