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In an analysis with follow-up censored on cessation of TZD the effect of cumulative exposure was slightly greater, consistent with a dropping off of effect on cessation (OR 1.33, 95% 1.10, 1.61, p = 0.003).
I drop off.
People predicted that things would drop off.
DoodyCalls picks up where pets drop off.
Drop off your car.
Drop off the face of the earth.
You can let these pieces drop off.
Considering a likely drop-off effect of 10%, we set the sample size of each group at five mice.
The greater effect when follow-up is censored at cessation is consistent with a dropping off of the effect when the drug is stopped, though we have not modelled this explicitly.
For each subject in each follow-up period, we considered the following possible exposure indexes: the average PM10 in their city in that follow-up period, and a model containing simultaneously the exposure during the follow-up period and each of the three previous years (distributed lag), to see if we could determine how the PM effect dropped off over time.
To put this in context, the strongest effects of age on any genes were 18% variance explained for TAC3 in brain and 29% for LRRN3 in lymphocytes, but in examining Tables 1, 2, 5 and 6, it is apparent that effect sizes drop off rapidly.
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