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This is in accordance with Moran et al. [ 8] who found a significant drop of rates of self-harm between 15.9 and 17.4 years of age.
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Taking into account an expected drop-out rate of 10% at the level of wards, and a 10% drop out rate of patients (withdrawal of informed consent), 44 wards (22 in each arm) with each 115 patients are included.
Additionally we compared the mean drop of heart rate (beats/min) in both sessions (Fig. 3).
Hyperoxia decreases cardiac output due to both a drop of heart rate [9] and a rise in vascular resistance [10].
Allowing for a drop out rate of 16%, this would mean enrolment of 158 into each arm of the study.
Taking into account a drop out rate of 25%, a sample size of approximately 230 claimants will be required.
To account for a drop out rate of up to 20%, we plan to randomise a total of 100 patients.
With an estimated drop out rate of 20%, 40 patients per group were needed for enrolment.
We estimate an overall drop out rate of about 10%%.
Assuming a drop out rate of 15%.[ 27], the total minimal sample size increases to 104.
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