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This induction coincided with an increase in the expressions of the proapoptotic genes p53 and bax and a drop in the expression of the antiapoptotic gene bcl-2.
Using this approach, they identified a pronounced molecular signature that is shared by disease risk genes due to haploinsufficiency, a type of genetic alteration that causes a dramatic drop in the expression of a particular protein.
Fig. 3) demonstrated that Cbl-b deficiency resulted in a higher expression of this cytokine but after chronic exposure for up to 4 weeks and 12 sessions, qPCR results (Fig. 4d) showed a drastic drop in the expression of IL-10 in Cbl-b−/− mice.
The participants who meditated reported reduced feelings of loneliness, and their blood tests indicated a significant drop in the expression of inflammation-related genes.
This analysis indicated that the drop in the expression of FLO11 depended on the first term of Equation 4, which essentially functions as a mechanism to restrict the expression of FLO11 under starvation.
These findings, in conjunction with those described above, show that a general drop in the expression of Tensins occurs in RCC and could therefore be favorable to the development of RCC tumors.
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Based on previous clinical observations of corneal perforations during topical fluoroquinolone treatment, we decided to evaluate the comparative effects of various fluoroquinolone eye drops on the expression of matrix metalloproteinases (MMPs) in cornea.
Removal of the downstream flanking area from the expression vector resulted in the 4-fold drop in the expression level.
However, in the Clic4 null mice, the drop in expression of CLIC5A following injury is much more prominent and the decline in level by 48 hours does reach the 95% confidence level.
Moreover, if the drop in expression of at least some of these genes precedes morphological changes in the pre-cancerous cells, the drop could be exploited for diagnostic proposes.
Here, we selected two mutations from either end of the spectrum: we report that the dysfunctional phenotype of point mutation L860P [14,15] was accounted for by a change in protein stability, which resulted in a drop in expression of functional channels.
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