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Here, we developed an HA-eye drop formulation that selectively binds and retains HA for extended periods of time on the ocular surface.
The higher the guar molecular weight, the lower was the CFC, the maximum concentration that can be tolerated in the eye drop formulation.
Alternatively, the development of a simple eye drop formulation would also be highly desirable.
Kuwano et al. [ 74] observed that micellar cyclosporine eye drop formulation affects its ocular distribution in rabbits and is also superior to nonmicellar formulation (control) with respect to the extent of drug penetration across corneal membrane and ocular tissue exposure.
Aggarwal et al. also reported that low birth weight infants fed oral iron in a drop formulation (3 mg/kg/day) for 8 weeks had significantly higher adjusted (for age, hemoglobin, ferritin, and maternal hemoglobin) hemoglobin concentrations from 4 weeks onwards compared with control infants [ 29].
Similar(54)
Development of biodegradable thermogels as intracameral injectable carriers for ocular delivery of antiglaucoma medications can provide a better treatment modality with low dosing frequency than eye drop formulations.
When an aqueous suspension of microparticles with PEG was administered topically to the rabbit eye in vivo, microparticles were seen for up to 30 min on the ocular surface in the cul-de-sac, which was a dramatic increase in residence time as compared to conventional eye drop formulations.
This need is indicated by the fact that even though anti-inflammatory drugs such as corticosteroid eye drop formulations reduce local inflammation, they can contain vehicles and distinct stabilizing compounds, which may impair wound healing process.
We tested the safety, maximal tolerated dose, pharmacokinetics, and antigenicity of a novel human recombinant NGF (rhNGF) eye-drop formulation in a phase I study.
Herein we present the results of a phase I clinical trial evaluating the safety of this topical rhNGF eye-drop formulation in healthy subjects.
Indeed, the main toxic effects of antiglaucoma treatments reported in the literature are related to the doses of preservative commonly used in eye-drop formulations.
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