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Although many enzymes driving this pathway have been identified, regulatory mechanisms underlying this system remain elusive.
Further studies will be required to test this positive-feedback-loop theory, and to identity other contributing factors that might be involved in driving this pathway towards the diseased state, in order to understand fully the link between GD and PD.
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We propose and find support for two distinct pathways driving this phenomenon – the candidate bid amounts (1) influence bidders' valuations of the offered product and (2) shape bidders' beliefs about what bid amounts will be successful.
The regulatory pathways driving this process are still largely unknown.
Identification of new therapeutic targets for SCC requires elucidation of the critical genes and pathways driving this disease.
Examples of the genes driving these pathways in the VMRs can be seen in Figure 6a e.
The close proximity of the TCA cycle and threonine biosynthesis, as well as the fact that the reactions driving these pathways as well as the genes governing them are well characterized, were major factors in our consideration.
These findings strongly indicate that p110β is the critical PI3K isoform driving PI3K pathway activation in this subset of cancer cells.
Given that overexpression of vascular growth factor receptors are not likely to directly lead to increased angiogenesis in ATCs, mTOR signaling emerges as a key angiogenesis driving pathway in this cancer.
In a comparative genomics approach, we employ the phylogenetic relation of Ae t. arabicum and A. thaliana to identify key factors driving GS pathway divergence.
On the other hand, the thalamo-cortical pathway that terminates in the superficial layers is thought to be modulatory, and the cortico-thalamic pathway from layer V appears to be a driving pathway [11], [18] [21].
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