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Taken together with the current findings, these data suggest that chronic progressive β-cell dysfunction is likely the dominant pathophysiologic defect driving the progression to type 2 diabetes in women with a history of GDM.
We hypothesize that there is a common functional mechanism driving the progression toward MDS on loss of 5q.
Among others changes in the enteric microbiome and an increased intestinal permeability contribute to an overflow of bacterial metabolites into the liver via the portal vein driving the progression of NAFLD.
Both, CancerSim and the continuum model suggested implicate cell death rather than genetic instability in driving the progression to cancer.
However, the initiating factors causing microvascular changes are the primary targets driving the progression of sporadic SVD need to be better understood.
Leveraging advancements in next-generation sequencing technologies, large-scale efforts have cataloged the somatic mutational events driving the progression of cancer [ 1- 3].
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Reported prognostic indicators may be complications of ADPKD that are exacerbated by disease progression, rather than factors driving the underlying progression of the disease, or may exhibit a cause-effect association, in which they both exacerbate and are worsened by the progression of the disease.
In conclusion, our analysis corroborated previous findings that innate immunity may be involved in the progression of PTSD, yet also identified candidate MRs driving the disease progression in the innate immunity pathways.
Considering that a fully developed neurodegenerative process may obscure the mechanisms driving the disease progression, we examined the expression of BDNF and TrkB mRNAs in mid-stage AD (BBIII-IV) when Capzb2 was specifically up-regulated (Figure 1, 2, 3, and 4).
Their epigenetic silencing could be one of the key factors driving the neoplastic progression in CRC.
Statistical analyses suggested that of the ~80 mutations in an individual tumor, < 15 were likely to be responsible for driving the initiation, progression, or maintenance of the tumor.
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CEO of Professional Science Editing for Scientists @ prosciediting.com