Sentence examples for driving pathology from inspiring English sources

One interpretation of these findings, consistent with the 'hyperfunction theory of aging' [ 2], is that the overactivity of AMPs is driving pathology and directly leading to death.

Moreover, in h1-120myc α-syn pff-treated culture, a Myc antibody dramatically reduced α-syn pathology, thereby providing unequivocal evidence that eliminating the exogenous source is driving pathology reduction.

Many of the extracellular stimuli driving pathology in RA do so through the activation of conserved intracellular signaling proteins and pathways, including NFκB, the mitogen-activated protein kinases, phospha-tidylinositol 3 kinases (PI3Ks) and the Janus tyrosine kinase (JAK /signal transducers and activators of transcription (STAT) pathway.

Animal models allow dissection of mechanistic pathways, which may be important in driving disease pathology.

Debate continues over the key etiologic process driving this pathology (Zimmet et al. 1999; Nesto 2004; Trayhurn 2005; Ziegler 2005).

These data provide insights into the mechanism of golimumab on inflammatory processes driving AS pathology, and may have utility in managing the treatment of patients with AS.

These data indicate IL-17 to be an important upstream proinflammatory cytokine driving joint pathology during flare-up of experimental arthritis and suggest therapeutic benefit of neutralizing IL-17 during relapses of rheumatoid arthritis.

One possible explanation is that, rather than extracellular Aβ plaque deposition, accumulation of Aβ inside neurons could be driving AD pathology, and may eventually lead to intracellular deficits in function and neuronal loss [ 25, 37, 68].

Indeed, it has been shown that conditioned medium from RA synovial membrane cultures activates human macrophages in a MyD88- and Mal-dependent manner, further strengthening the involvement of an endogenous TLR ligand driving RA pathology [ 52, 53].

Our data imply that SFB mediates its effects on murine NAFLD by way of its effects on induction of IL-17 signaling, consonant with the role of SFB in driving extraintestinal pathology through activation of the IL-17 axis in other mouse models of inflammatory disease.

The present study highlights the role of DEE composition in driving divergent pathologies.