Sentence examples for driving hypothesis from inspiring English sources

The driving hypothesis of this article is that the antibody-mediated immune response triggered by V520 suppressed the ability of the body to mount the cell-mediated immune response necessary to protect against HIV and created a window of opportunity for HIV infection, particularly in subjects previously exposed to the adenovirus vector used in the vaccine.

The driving hypothesis was that by stratifying the entire population into subgroups based on some clinically motivated features, we could build a better overall classifier.

The driving hypothesis behind social franchising is that a network operating under this type of contractual arrangement can deliver improved health services in terms of access and quality [ 3].

Because challenges are posed by the unique curriculum and mode of research training offered by each graduate program, especially when field-based research is used rather than bench-based research, a common format was developed in which each IMSD student provides the title of his or her research project, a clearly stated driving hypothesis, and the methodology.

Bone fracture healing shares many features with bone development, driving the hypothesis that the regenerative process generally recapitulates development.

Our ΔΨ-driving hypothesis on Fo motor is an attempt to unveil the robust mechanism of energy conversion in the highly conserved, ubiquitously expressed rotary ATP synthases.

In this article, we propose the application of the same ΔΨ-driving hypothesis for identifying the mechanism of the functional cycle of the Fo motor.

One of the models, referred to here as the rigid-rotor model, will be further refined in light of newly available structural information and in the framework of our ΔΨ-driving hypothesis.

In support of the refined rigid-rotor model following our ΔΨ-driving hypothesis, an E. coli aR210A variant showed proton leakage and abolished coupling between ATP hydrolysis in F1 and proton translocation in Fo (Valiyaveetil and Fillingame, 1997).

Here, we propose a mechanism of unidirectional rotation of the Fo complex, which is in agreement with these new structural insights as well as our more general ΔΨ-driving hypothesis of membrane proteins: A proton path in the rotor-stator interface is formed dynamically in concert with the rotation of the Fo rotor.

As such, our data provide a valuable resource for interpreting disease mechanisms, connecting findings from one neurodegenerative disease to another, and driving novel hypotheses.