Sentence examples for driving alterations in from inspiring English sources

Novel driving alterations in cancer provide the opportunity for the discovery of potential molecular targets in cancer, and the identification of prognostic and diagnostic alterations.

The reason is that the hypothalamus interacts with numerous organs and tissues, driving alterations of homeostasis.

Alterations in mitochondrial function and energy metabolism is an emerging hallmark of cancer, however, the potential role that obesity plays in driving these alterations in EAC is currently unknown.

Both CCs and GGPs may play the role of reactant (entity undergoing the alteration), product (entity into which the reactant is changed) or modifier (entity driving the alteration) in a metabolic process.

Other driving genomic alterations, such as in ALK and c-MET genes, have also been gaining recent attention.

The correlation coefficients between CNV and expression abundances of differentially expressed genes were even lower than for other genes, suggesting that CNV is not a major factor in driving expression alterations during KIRC cancer progression.

In this condition, TGF-β is driving fibrotic alterations and epithelium-dependent fibroblast activation [ 44].

However, genomic profiling poses a significant challenge to uncover driving genomic alterations from the large number of deletions and amplifications present in cancer genomes.

In fact, the presence of SP cells in tumors was found to be highly dependent on the driving genetic alterations of the tumor.

We emphasize the importance of macro-evolutionary leaps, often involving large-scale chromosomal alterations, in driving tumor evolution and metastasis and consider the role of the tumor microenvironment in engendering heterogeneity and drug resistance.

In the pathogenesis of NSCLC exposure to tobacco carcinogens in addition to clonal selection may be the driving force in these alterations.