Sentence examples for drives aggressive from inspiring English sources

In summary, this work has identified CYCLON as a new MYC cooperating factor that autonomously drives aggressive tumour growth and Rituximab resistance in lymphoma.

High levels of this oncogene, almost invariably as a consequence of genomic amplification of a region of chromosome 17 (17q21) including the HER2 locus, drives aggressive disease and is an important therapeutic target.

Array device scaling is determined by a chip size driven aggressive node scaling.

After 2003, Korean semiconductor firms had driven aggressive investment into facilities and equipment to expand their market power.

Therefore, identifying cellular components and molecular mechanisms that drive aggressive PCa at early stage is critical for disease prognosis and therapeutic intervention.

More mysterious are the features of ccRCC biology that drive aggressive disease and underlie lethality.

Frequencies of p53 mutations are low in primary MB but Increase significantly in recurrences, and mutant p53 proteins and Myc may collaborate to drive aggressive disease [ 8].

Furthermore, CYCLON was identified to be an autonomous tumour growth driver that cooperates with MYC to drive aggressive lymphoma growth in vivo thus further rationalizing the value of therapeutically targeting this factor in lymphoid malignancies.

As described above, overexpressed Ets TFs are major players in cancer development and can drive aggressive disease, hence they have been identified as significant targets for drug development [ 5, 56].

As described, the cellular FRAP assay can detect whether a compound can modulate chromatin binding (i.e., the diffusion rate) of transfected GFP-tagged bromodomains, but the FRAP assay lacks sufficient sensitivity or throughput to rank-order inhibitor potency to drive aggressive lead optimization programs.

doi: 10.1111/cas.12343 Brain gliomas carry a poor prognosis and, although they rank among the most common primary brain tumors, little is understood of what drives their aggressive behavior.