Sentence examples for drivers of tissue from inspiring English sources

This newly developed approach can be used to predict free drug concentration in diverse tissue compartments for small molecules in toxicology and pharmacology studies, which can be leveraged to optimize the pharmacokinetics drivers of tissue distribution based upon physicochemical and physiological input parameters in an attempt to optimize free drug level in tissue.

These strategies will be accelerated by understanding drivers of tissue response to IR that can be correlated with the specific genetic background of individual patients.

For example, both miR-155 and miR-326 are induced during T-cell activation and their upregulation is critical for proper differentiation of T cells to Th17 effector cells, which are drivers of tissue inflammation [ 17, 21, 22].

Mucosal innate immune responses are a prerequisite for eliciting adaptive immune responses, as well as for eliciting the adaptive immune responses, which may become the major drivers of tissue injury and establishment of chronic inflammation.

The authors develop a method to extract cell-level contributions to tissue area changes and tissue shear, and demonstrate that the various drivers of tissue shape are changing with time in interesting and robust patterns.

The main drivers of tissue-specific effects are listed in table 2. These genes were singled out in this study as genes the removal of which increased relative correlation score by ≥5% of the observed value.

Myofibroblast activity is clearly a key driver of tissue fibrosis and shrinkage in IPF [ 45- 47].

These miRNAs regulate the severity of the disease by influencing Th17 development, which is an important driver of tissue inflammation [ 21, 22].

The quantity of adipose tissue is an important driver of adipose tissue dysfunction, insulin resistance and cardiovascular disease.

Knockdown of pacman expression in specific domains of the wing disc using various GAL4 drivers resulted in loss of tissue in the corresponding domains of the adult wing (Fig. 5).

It facilitates the differentiation of fibroblasts, hepatic stellate cells [ 7], fibrocytes [ 8], and epithelial cells [ 9] into myofibroblasts, the drivers of collagen deposition and tissue contraction.