Sentence examples for drivers of response from inspiring English sources
In this review, we have listed the currently identified PD drivers of response and predictors of OS for oncology drugs and their cancer indication (Tables 4).
Therefore, while alterations in specific RAS pathway components have lead to an increased understanding of the molecular drivers of response to EGFR inhibition in colorectal cancer, the relationship between KRAS mutation, RAS pathway dependence, and drug response is less clear in NSCLC and other tumor types.
These findings highlight the importance of better understanding heterogeneity in the specific drivers of responses to health risk information.
By convention, established PK/PD analysis methods/models assume that concentration is the main driver of response.
Xie et al. [ 60] applied such a model to predict diarrhoea after receiving irinotecan using AUC as a driver of response.
Henin et al. [ 61] developed a proportional odds ratio model with a Markov process to predict HFS in patients receiving capecitabine using cumulative dose as a driver of response.
Factors such as the drug mechanism of action and the time frame of PD response, as it relates to the driver and dosing scheme, should be considered when assessing drivers of PD response.
Effective marketing is a never-ending quest to understand the contextual drivers of customer response.
Further, Roche signed a partnership with GNS Healthcare in June 2017 to use its REFS (Reverse Engineering and Forward Simulation) technology to analyze proprietary EHR and next-generation sequencing data for insights on drivers of drug response and cancer progression.
We initially utilized PCA in order to identify the subsets of mediators that are most strongly correlated with ST or ST + HS, and that thereby might be considered principal drivers of each response.
The goal of this analysis was to identify the subsets of mediators (in the form of orthogonal normalized linear combinations of the original mediator variables, called principal components) that are most strongly correlated with a given experimental procedure (ST or ST+HS), and that thereby might be considered principal drivers of each response.
