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A series of one-way sensitivity analyses were performed to establish key drivers of outcomes.
These studies also received low scores as a result of limited sensitivity analyses and lack of transparency, as very limited information on the outcomes and drivers of outcomes were given.
The results of one-way sensitivity analyses identified the key drivers of outcomes as patient age, the cost of Onco type DX testing and changes in chemotherapy recommendations for patients deemed to be at low risk of distant recurrence.
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As others have shown, severity of illness was the main driver of outcomes.
Even among these patients with significant disease, the exact timing of antimicrobial therapy did not appear to be the main driver of outcomes.
Previous studies have shown that vaccine coverage in girls is a key driver of outcomes in both males and females [ 18, 19].
In addition, within Europe there are wide variations in vaccine uptake rates, screening coverage, HPV prevalence and transmission rates, and as shown here, vaccination uptake rates are a key driver of outcomes.
The single biggest driver of outcomes was patient age; decreasing the mean age to 45 years (versus 60.55 years in the base case) led to an ICER of GBP 4628 per QALY gained, whereas increasing patient age to 75 years led to an ICER of GBP 16 537 per QALY gained.
36 The findings that BNP is the primary driver of outcomes, and that adding LVEF has limited value in prognostication, have been reported previously in patients with acute HF 37 and in a recent community study, 38 but these facts may also be true in chronic HFpEF.
For these reasons, it has been suggested that traditional statistical techniques are not well suited for analyzing drivers of health outcomes and no traditional approach can control all external factors affecting patient health outcomes [ 8].
More specifically, we look at the spatial effects and the main structural drivers of the outcomes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com