DOI: http://dx.doi.org/10.7554/eLife.05564.004 The mean and variance of the incubation period have been recognized as key drivers of the effectiveness of fever screening at arrival, since shorter incubation periods mean a greater likelihood that travellers will progress to symptoms during travel (Pitman et al., 2005; Al-Tawfiq et al., 2014; Mabey et al., 2014).
The univariate sensitivity analysis showed that main drivers of cost-effectiveness were the treatment effect and the discontinuation rate.
8, 12, 14, 15 Thus, herd effects among adults are the major drivers of cost-effectiveness estimates when considering PCV recommendations for children.
In contrast, HbA1c and weight were the key drivers of cost-effectiveness in the liraglutide vs. sitagliptin comparison, with only small effects from systolic blood pressure and cholesterol, reflecting the greater effect of liraglutide vs. sitagliptin on reducing HbA1c and weight, and the comparable effects of both of these therapies on systolic blood pressure and cholesterol [ 11].
However, common drivers of cost-effectiveness included those affecting the number of RSV hospitalisations and those affecting costs.
Given many studies found non-significant differences in costs between interventions, differences in health outcomes have the capacity to be the main drivers of cost-effectiveness.
Rather than culture costs per se, the primary drivers of cost-effectiveness included clinical practices (e.g., empiric TB treatment), communications or patient follow-up (e.g., translating culture results into treatment), and TB prevalence.
